Low-dose endotoxin induces non-overt disseminated intravascular coagulation in rabbits

刘宿; 蒋耀光; 王韶亮; 王伍超

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Low-dose endotoxin induces non-overt disseminated intravascular coagulation in rabbits

更新时间：2026-01-09

- Low-dose endotoxin induces non-overt disseminated intravascular coagulation in rabbits
- Journal of Army Medical University Vol. 29, Issue 9, Pages: 782-785(2007)
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  CLC： R-332;R554.8
- Published：2007
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刘宿,蒋耀光,王韶亮,王伍超.低剂量内毒素诱导兔非显性弥散性血管内凝血[J].陆军军医大学学报(原第三军医大学学报),2007,29(09):782-785.

　LIU Su,JIANG Yao-guang,WANG Shao-liang,WANG Wu-chao.Low-dose endotoxin induces non-overt disseminated intravascular coagulation in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(09):782-785.
刘宿,蒋耀光,王韶亮,王伍超.低剂量内毒素诱导兔非显性弥散性血管内凝血[J].陆军军医大学学报(原第三军医大学学报),2007,29(09):782-785. DOI：

　LIU Su,JIANG Yao-guang,WANG Shao-liang,WANG Wu-chao.Low-dose endotoxin induces non-overt disseminated intravascular coagulation in rabbits[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(09):782-785. DOI：

摘要

目的用低剂量内毒素诱导兔非显性弥散性血管内凝血，观察凝血、纤溶变化及肝素抗凝治疗的效果。方法 12只雄性新西兰兔按完全随机设计方法分为内毒素组和内毒素加肝素治疗组，每组6只，采用内毒素10 μg/kg由颈内静脉注入，其中肝素组在注入内毒素同时加用肝素100 U/kg抗凝治疗。以实验前样本作自身对照，实验后1、2、3、6 h分别采取静脉血进行凝血酶原时间（PT）、活化部分凝血酶原时间（aPTT）、凝血酶时间（TT）、纤维蛋白原（Fib）含量及D-二聚体含量测定、血栓弹力图（TEG）各参数变化以及肺、肾脏病理改变。结果内毒素组PT、aPTT、TT均延长，Fib含量降低，D-二聚体含量明显增加，TEG示凝血因子消耗、血小板减少，肺、肾内有微血栓形成；肝素组凝血象变化不明显，D-二聚体含量有增加，TEG示轻微低凝状态，肺、肾内未见微血栓形成。结论低剂量内毒素能诱导兔非显性弥散性血管内凝血，且抗凝治疗有效。

Abstract

Objective To study the changes of coagulation and fibrinolysis in rabbit model of non-overt disseminated intravascular coagulation induced by low-dose endotoxin and therapeutic effects of anticoagulation by heparin. Methods Twelve male rabbits were randomly divided into 2 groups

one receiving endotoxin intravenously (10 μg/kg

n=6)

one receiving endotoxin intravenously and 100 U/kg Heparin simultaneously (n=6). The blood sample obtained before experiment was used as control. Coagulation parameters including prothrombin time (PT)

activated partial thromboplastin time (aPTT)

thrombin time (TT)

fibrinogen concentration

D-dimers

thrombelastography (TEG) were measured during 6 h after endotoxin induction. Tissue specimens of lungs and kidneys were examined. Results Parameters of coagulation deteriorated significantly in the endotoxin-induced rabbits

but was not altered in heparin-treated rabbits. TEG monitoring in the endotoxin-induced rabbits reflected consumption of clot factors and platelet dysfunction

and hypocoagulation status in heparin-treated rabbits. In endotoxin-induced group

fibrin deposition was found in lungs and kidneys. Conclusion Non-overt disseminated intravascular coagulation induced by low-dose endotoxin in rabbits is improved by heparin.

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