Influence of hypoxia on leptin expression in C57BL/6J mice

刘茜; 吴亚梅; 徐玲; 唐超; 种银保

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Influence of hypoxia on leptin expression in C57BL/6J mice

更新时间：2026-01-09

- Influence of hypoxia on leptin expression in C57BL/6J mice
- Journal of Army Medical University Vol. 29, Issue 13, Pages: 1311-1312(2007)
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  CLC： R341;R364.4;R446.1
- Published：2007
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刘茜,吴亚梅,徐玲,唐超,种银保.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1311-1312.

　LIU Xi,WU Ya-mei,XU Ling,TANG Chao,ZHONG Yin-bao.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1311-1312.
刘茜,吴亚梅,徐玲,唐超,种银保.急性缺氧诱导C57BL/6J小鼠瘦素表达增加[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1311-1312. DOI：

　LIU Xi,WU Ya-mei,XU Ling,TANG Chao,ZHONG Yin-bao.Influence of hypoxia on leptin expression in C57BL/6J mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1311-1312. DOI：

摘要

目的观察缺氧后小鼠血清和中枢神经系统瘦素水平的变化。方法以C57BL/6J小鼠为研究对象，利用医学自动测控缺氧仓(XQ-I型)复制机体常压缺氧状态，分为正常组、缺氧24 h组、缺氧48 h组，收集小鼠血清、脑脊液和脑组织（去除大脑和小脑后）匀浆标本，利用放射免疫方法检测瘦素浓度。结果缺氧24、48 h组小鼠血清、脑脊液和脑组织内的瘦素水平均显著高于未缺氧小鼠(P0.05)，但缺氧24 h组和缺氧48 h组之间没有明显差别(P0.05)。结论缺氧可作为一种独立的诱导因素促进小鼠脂肪组织瘦素的表达，同时使进入中枢神经系统内的瘦素水平亦明显增加。

Abstract

Objective To investigate the influence of hypoxia on leptin expression in serum

CSF and brain tissue of C57BL/6J mice. Methods C57BL/6J mice were divided into 3 groups: the normal control

24-hour hypoxia group and 48-hour hypoxia group. The latter two groups exposed to hypoxia in the man-made auto pressure and hypoxia control cabin (XQ-I). Radioimmunoassay was used to detect the leptin level. Results The leptin level in the serum

CSF and brain tissue of mice exposed to hypoxia were higher than that of normal control

but no difference was found between 24-hour hypoxia group and 48-hour hypoxia group. Conclusion Hypoxia probably induces the increasing of leptin expression in fat tissue

as well as in the central nervous system.

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Related Institution

Institute of Immunology, College of Basic Medical Science，Army Medical University （Third Military Medical University）

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Department of Cardiovascular Medicine， First Affiliated Hospital, Second Affiliated Hospital， Army Medical University （Third Military Medical University）

Department of Pathophysiology， Faculty of High Altitude Military Medicine, Second Affiliated Hospital， Army Medical University （Third Military Medical University）

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