Objective     To evaluate the potential role of STAT3 Decoy ON on the proliferation and the survival of tumor-bearing nude mice

and to explore the effect of STAT3 Decoy ON on the abdomino-plantation of human gastric carcinoma in nude mice.      Methods     The human gastric cancer cell MKN-45 was employed in the study. The inhibitory effect of STAT3 Decoy ON on the proliferation of cancer cells was quantified by MTT assay. The DNA-binding activities of STAT3 were detected by EMSA method. The nude mice were randomly divided into 4 groups and treated with different methods. The formation of tumor

the production of ascites

the death rate and survival period of tumor-bearing nude mice were evaluated.      Results     STAT3 Decoy ON inhibited the proliferation of the tumor cells in time dependent manners. STAT3 Decoy ON could inhibit the DNA-binding activities of STAT3 of gastric adenocarcinoma cell MKN-45. Compared with other groups

STAT3 Decoy ON could reduce the production of ascites and the death rate of tumor-bearing nude mice

prolong the survival period of tumor-bearing nude mice significantly (P0.05).      Conclusion     STAT3 Decoy ON could inhibit abdomino-plantation and relapse of gastric cancer in tumor-bearing nude mice.