Changes and clinical significance of coagulation function of patients with lung cancer or  esophagus cancer in thoracotomy

刘宿; 蒋耀光; 葛衡江; 唐小唪

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Changes and clinical significance of coagulation function of patients with lung cancer or esophagus cancer in thoracotomy

更新时间：2026-01-09

- Changes and clinical significance of coagulation function of patients with lung cancer or esophagus cancer in thoracotomy
- Journal of Army Medical University Vol. 29, Issue 9, Pages: 779-781(2007)
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  CLC： R552.06;R730.56;R734.2
- Published：2007
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刘宿,蒋耀光,葛衡江,唐小唪.肺癌食管癌开胸手术患者术中凝血功能改变及其临床意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(09):779-781.

　LIU Su,JIANG Yao-guang,GE Heng-jiang,TANG Xiao-feng.Changes and clinical significance of coagulation function of patients with lung cancer or esophagus cancer in thoracotomy[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(09):779-781.
刘宿,蒋耀光,葛衡江,唐小唪.肺癌食管癌开胸手术患者术中凝血功能改变及其临床意义[J].陆军军医大学学报(原第三军医大学学报),2007,29(09):779-781. DOI：

　LIU Su,JIANG Yao-guang,GE Heng-jiang,TANG Xiao-feng.Changes and clinical significance of coagulation function of patients with lung cancer or esophagus cancer in thoracotomy[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(09):779-781. DOI：

摘要

目的应用血栓弹性描记仪观察肺癌、食管癌开胸手术患者围术期凝血功能的改变。方法择期行手术治疗的肺癌患者10例，中段或上段食管癌患者10例，观察麻醉前5 min（T

）、手术开始后1 h（T

）、手术结束后30 min（T

）血栓弹性描记仪参数中反应时间（reaction time， R）、凝血形成时间（clotting time， K）、α角（α angle）和最大振幅（maximum amplitude， MA）等指标的变化。10例健康志愿者为对照组。结果与正常对照组相比，肺癌患者和食管癌患者术前R值缩短，相差显著（P0.05）。肺癌患者T

时间点R值、K值延长，α角和MA减小，与T

比较相差显著（P0.05），术后T

时间点仍然有MA减小，与T

比较相差显著（P0.05）；肺癌患者与食管癌患者相比在T

时间点R、K延长，α角和MA减小，相差显著（P0.05），T

时间点α角和MA减小，两组比较相差显著（P0.05）；纤溶指数LY

值在T

、T

时间点与T

比较以及同时间点与食管组比较相差显著（P0.05）。食管癌患者术中、术后TEG变化与T

比较相差均无显著性(P0.05)，T

时间点CI(coagulation index)值与T

比较相差显著（P0.05）；T

时间点与肺癌组比较，R、K有缩短。结论两组恶性肿瘤患者术前可能存在高凝状态，肺癌组患者术中、术后凝血功能逐渐趋于低凝状态，而食管癌组患者术中、术后继续有高凝的趋势。

Abstract

Objective To study the coagulation of patients with lung cancer or esophagus cancer in thoracotomy during perioperative period. Methods Variables [reaction time (R)

clotting time (K)

α angle

maximu

m amplitude (MA)

]

detected by thrombelastography were measured in 10 cases of lung cancer and 10 cases of upper or median esophagus cancer before anesthesia (T

)

at the end of 1 h after operation beginning (T

) and 30 min after operation (T

). The control group consisted of 10 healthy volunteers. Results In lung cancer group and esophagus cancer group

R was shorter than control group (P0.05). R and K were longer

α angle and MA were smaller at T

than at T

(P0.05)

and MA was smaller at T

than at T

in lung cancer group. R and K were longer

α angle and MA were smaller at T

and α angle and MA were smaller at T

in lung cancer group than in esophagus group (P0.05). LY

(fibrinolysis index) at T

and T

was longer in lung cancer group than in esophagus cancer group (P0.05). CI （coagulation index） was longer at T

in esophagus cancer group than in lung cancer group (P0.05). Conclusion Patients with lung cancer or esophagus cancer have possibility of hypercoagulability before operation. Coagulability of lung cancer patients decreased during and after operation

and hypercoagulability of esophagus cancer patients continued during and after operation.

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