Effect of lead on calcium absorption and bone development in weanling rats

胡雪琴; 糜漫天

您当前的位置：

首页 >

文章列表页 >

Effect of lead on calcium absorption and bone development in weanling rats

更新时间：2026-01-09

- Effect of lead on calcium absorption and bone development in weanling rats
- Journal of Army Medical University Vol. 29, Issue 5, Pages: 402-405(2007)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC： R151.3;R336;R339.31
- Published：2007
- 稿件说明：
移动端阅览
胡雪琴,糜漫天.铅对幼年大鼠钙的吸收和骨骼生长的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(05):402-405.

　HU Xue-qin,MI Man-tian.Effect of lead on calcium absorption and bone development in weanling rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(05):402-405.
胡雪琴,糜漫天.铅对幼年大鼠钙的吸收和骨骼生长的影响[J].陆军军医大学学报(原第三军医大学学报),2007,29(05):402-405. DOI：

　HU Xue-qin,MI Man-tian.Effect of lead on calcium absorption and bone development in weanling rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(05):402-405. DOI：

摘要

目的研究铅对大鼠钙的吸收和骨骼生长的影响。方法分别以纯净水和1.0 g/L醋酸铅水饲喂Wistar大鼠，其中醋酸铅饲喂大鼠又分别以正常饲料、高钙饲料和低钙饲料饲养，对应分组为对照组、单铅染毒组、高钙铅染毒组和低钙铅染毒组。观察大鼠生长发育

测定大鼠血清中骨钙素和甲状旁腺激素的含量，检测骨骼中铅和钙的含量，石蜡切片HE染色比较大鼠股骨显微结构变化。另饲养10只Wistar大鼠，以

CaCl

示踪研究铅对钙吸收的影响。结果铅和低钙处理明显抑制大鼠生长发育，使大鼠股骨的长度和直径减小，且低钙加剧了铅对骨骼的抑制作用，而高钙则拮抗铅对骨骼的抑制作用。示踪结果显示铅可显著抑制大鼠体内钙的吸收。结论铅可能通过抑制大鼠体内钙的吸收而使骨骼生长受限，补充适量钙有助于减轻铅对骨骼生长的抑制。

Abstract

Objective To study the effect of lead on the calcium absorption and bone development in weanling rats. Methods Totally 80 weanling Wistar rats were equally divided into normal control (given with pure water and standard feed

including 1.15% calcium)

lead group (given 1.0 g/L lead acetate water and standard feed)

lead+low calcium group (1.0 g/L lead acetate water and feed including 0.69% calcium)

and lead+high calcium group (1.0 g/L lead acetate water and feed including 1.72 % calcium). The development of rats was observed. Serum contents of osteocalcin and parathormone，and bone levels of lead and calcium in the femur were determined. The femur was examined with histological method. Another 5 Wist

ar rats received gastric irrigation of 10% lead acetate for 5 d

5 more rats served as control

and then their absorption of calcium was detected with

CaCl

. Results Lead and low calcium inhibited the development of rat remarkably

with the content of osteocalcin

the length and diameter of the femur decreased. High calcium antagonized these effects of lead. The absorption of calcium in rats was repressed by lead. Conclusion Bone depression by lead may be due to that lead inhibits the absorption of calcium in rats

and the supplement of calcium is helpful to minimize the repression.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Neuroprotective effects and mechanisms of osteocalcin in an Alzheimer’s disease cell model

Knocking out p75 neurotrophin receptor suppresses mineralization in the femurs of mice

Rapid elevation of calcium concentration in astrocytes of rat spinal dorsal horn by dexamethasone

Effect of novel dynamic compressive interlocking intramedullary nail on fracture healing

Establishment and evaluation of mouse femur critical bone defect model

Related Author

FANG Lilin

ZHU Qifeng

ZHANG Mingda

CUI Man

LU Shijin

YAN Yu

Luchuan Liu

Yingying Wang

Related Institution

Graduate School of Guangxi University of Chinese Medicine

Department of Neurology

Center for Integrated Traditional Chinese and Western Medicine， Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine

Department of Encephalopathy， Pingnan County Hospital of Chinese Medicine

Department of Stomatology, Institute of Surgery Research, Daping Hospital, Third Military Medical University

⁰