Objective     To establish three-dimensional coordinate system of cerebrum and measure the main structure of cerebrum in 3D.       Methods     Visible human technique was used to collect transverse image of human cerebrum. On segmentation and three-dimensional model of cerebrum

the tridimensional coordinate system was established and the main structures of cerebrum were measured and localized by using the software exploited by our research group.      Results     The tridimensional coordinate system was established on the midpoint of intercomissural distance. The original data was resampled to aquire the human cerebrum dataset matched with the new coordinate system. The volume and space coordinate of cerebral cortex

white matter

basal nuclei

lateral venticle and hippocampus were measured. And the localization of the main structures of cerebrum in 3D space was obtained.      Conclusion     It is a new approach to look for zero in building the cerebral coordinate system and establish the new coordinate system on computer. The volume data of the main structure of cerebrum is real and exact

and contributes to the quantitative data accumulation of the cerebral anatomic model.