Expression of inhibitor of DNA binding-2 in spinal cord of adult rats

高宇; 陈兴书; 余洪俊; 刘宏亮; 姚忠祥

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Expression of inhibitor of DNA binding-2 in spinal cord of adult rats

更新时间：2026-01-09

- Expression of inhibitor of DNA binding-2 in spinal cord of adult rats
- Journal of Army Medical University Vol. 29, Issue 7, Pages: 592-594(2007)
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  CLC： R322.81;R341;R446.61
- Published：2007
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高宇,陈兴书,余洪俊,刘宏亮,姚忠祥.DNA结合抑制因子2在成年大鼠脊髓表达的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):592-594.

　GAO Yu,CHEN Xing-shu,YU Hong-jun,LIU Hong-liang,YAO Zhong-xiang.Expression of inhibitor of DNA binding-2 in spinal cord of adult rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):592-594.
高宇,陈兴书,余洪俊,刘宏亮,姚忠祥.DNA结合抑制因子2在成年大鼠脊髓表达的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(07):592-594. DOI：

　GAO Yu,CHEN Xing-shu,YU Hong-jun,LIU Hong-liang,YAO Zhong-xiang.Expression of inhibitor of DNA binding-2 in spinal cord of adult rats[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(07):592-594. DOI：

摘要

目的探讨螺旋环螺旋基因家族(helix-loop-helix

HLH )成员DNA结合抑制因子2 (inhibitor of DNA binding 2

Id2)在大鼠脊髓中的表达。方法 Zambonis 液灌注固定大鼠脊髓组织

切片进行免疫组织化学(ABC法) 染色。结果 Id2免疫阳性细胞在脊髓中广泛分布

在Ⅰ~Ⅲ板层及Ⅸ板层Id2主要在细胞核表达

细胞质表达少。Ⅳ~Ⅷ板层细胞质及细胞核均有Id2表达。从Ⅳ到Ⅷ板层

Id2细胞质阳性细胞体积逐渐增大

染色较深。结论 Id2广泛分布在大鼠脊髓灰质各个板层

不同板层中Id2的细胞定位不同

可能分布于不同类型的细胞中。

Abstract

Objective To investigate the expression of the helix-loop-helix (HLH) transcription factor Id2 (inhibitor of DNA binding-2) in spinal cord of adult rats. Methods Immunohistochemistry was performed on the sections of spinal cord of rats perfused with Zambonis. Results The positive Id2-immunoreactive cells distributed in the spinal cord extensively. In lamina Ⅰ-Ⅲ

the expression of Id2 was predominantly in nucleus and few in cytoplasm

the same as lamina Ⅸ. In lamina Ⅳ-Ⅷ

positive Id2 immunoreactivity was present in both cytoplasm and nucleus. The volume of positive cells was larger and their staining got deeper from lamina Ⅳ to lamina Ⅷ gradually. Conclusion Id2 protein is widely distributed in grey matter of spinal cord of rats. The cellular location of Id2 different in laminas might be associated with cell type.

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