Preparation of ADM-PLGA sustained release nanospheres and their release characteristics in vitro

卢来春; 张蓉; 张纲; 黄林清; 刘同华

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Preparation of ADM-PLGA sustained release nanospheres and their release characteristics in vitro

更新时间：2026-01-09

- Preparation of ADM-PLGA sustained release nanospheres and their release characteristics in vitro
- Journal of Army Medical University Vol. 29, Issue 13, Pages: 1280-1281(2007)
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  CLC： R943;R944.9;R979.14
- Published：2007
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卢来春,张蓉,张纲,黄林清,刘同华.ADM-PLGA缓释纳米微球的制备及体外释药的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1280-1281.

　LU Lai-chun,ZHANG Rong,ZHANG Gang,HUANG Lin-qing,LIU Tong-hua.Preparation of ADM-PLGA sustained release nanospheres and their release characteristics in vitro[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1280-1281.
卢来春,张蓉,张纲,黄林清,刘同华.ADM-PLGA缓释纳米微球的制备及体外释药的研究[J].陆军军医大学学报(原第三军医大学学报),2007,29(13):1280-1281. DOI：

　LU Lai-chun,ZHANG Rong,ZHANG Gang,HUANG Lin-qing,LIU Tong-hua.Preparation of ADM-PLGA sustained release nanospheres and their release characteristics in vitro[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(13):1280-1281. DOI：

摘要

目的制备ADM-PLGA纳米微球，观察其一般特性、载药量、包封率和缓释特性。方法采用超声乳化法制备缓释ADM-PLGA-Ns纳米微球，观察其一般特性，采用高效液相法测定ADM含量，并模拟体内条件研究ADM-PLGA-Ns纳米微球的体外缓释特性。结果纳米微球表面光滑圆整，球体大小均匀，粒径为（21±5.4）nm，微球包封率和载药量分别为(89.71±7.31）%和(0.75±0.54)%。微球体外释药符合Higuichi方程

10 d后释放度达95.00%。结论 ADM-PLGA纳米微球制备工艺效果满意，具有明显的缓释作用。

Abstract

Objective To prepare ADM-PLGA nanospheres (ADM-PLGA-Ns) and investigate their general characteristics

drug release characteristics in vitro. Methods The ADM-PLGA-Ns were prepared by W/O/W multiple emulsion volatilizing method. Their general properties were observed. HPLC was used to measure the content of ADM. In vivo conditions were simulated to study ADM-PLGA-Ns release characteristics. Results The ADM-PLGA-Ns were even and uniform spheres with mean particle size of (21±5.4) nm in diameter. The drug loading amount and encapsulation efficiency of ADM-PLGA-Ns were (89.71±7.31)% and (0.75±0.54)% respectively. The in vitro release profile of ADM-PLGA-Ns was figured by Higuichi equation. The drug release reached 95.00％ at the 10th day. Conclusion The prepared ADM-PLGA-Ns have good properties including sustained release in vitro.

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