Objective     To explore the roles of cervical sympathetic ganglia block (SB) in glucocorticoid receptor（GR）

protein levels and proinflammatory cytokine release of peritoneal macrophage in mice with combined radiation and burn injury.      Methods     Thirty-two Kunming mice were divided into control group

injury group (inflicted with 5 Gy irradiation and 15% TBSA full thickness burn injury)

unilateral SB (inflicted with injury

treated daily by unilateral cervical SB) and bilateral SB group (inflicted with injury

treated daily by bilateral cervical SB). The roles of SB were evaluated by comparing GR protein levels and proinflammatory cytokine (TNF-α

IL-1β

IL-6) release of peritoneal macrophage in each group.      Results     Compared with control group

GR protein levels in injury group decreased significantly. The levels of unilateral SB and bilateral SB group were lower than that of control group but higher than that of injury group. Proinflammatory cytokine (TNF-α

IL-1β

IL-6) release in unilateral SB and bilateral SB groups was higher than that in control group but significantly lower than injury group. There were no significant differences of GR protein levels and proinflammatory cytokine (TNF-α

IL-1β

IL-6) release between unilateral SB and bilateral SB groups.      Conclusion     Bilateral SB and unilateral SB can be an effective therapeutic approach for ameliorating GR function and controlling inflammatory response of peritoneal macrophage following severe trauma.