Correlation between VEGF-C/D expressions in tumor associated macrophages and lymph node metastasis in colon cancer

李焱; 蒋勇; 史立群; 史爱学; 彭亦良; 梁后杰

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Correlation between VEGF-C/D expressions in tumor associated macrophages and lymph node metastasis in colon cancer

更新时间：2026-01-09

- Correlation between VEGF-C/D expressions in tumor associated macrophages and lymph node metastasis in colon cancer
- Journal of Army Medical University Vol. 29, Issue 2, Pages: 157-159(2007)
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  CLC： R392.2;R73-37;R735.35
- Published：2007
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李焱,蒋勇,史立群,史爱学,彭亦良,梁后杰.结肠癌组织肿瘤相关巨噬细胞VEGF-C/D的表达及与淋巴结转移的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(02):157-159.

　LI Yan,JIANG Yong,SHI Li-qun,SHI Ai-xue,PENG Yi-liang,LIANG Hou-jie.Correlation between VEGF-C/D expressions in tumor associated macrophages and lymph node metastasis in colon cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(02):157-159.
李焱,蒋勇,史立群,史爱学,彭亦良,梁后杰.结肠癌组织肿瘤相关巨噬细胞VEGF-C/D的表达及与淋巴结转移的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(02):157-159. DOI：

　LI Yan,JIANG Yong,SHI Li-qun,SHI Ai-xue,PENG Yi-liang,LIANG Hou-jie.Correlation between VEGF-C/D expressions in tumor associated macrophages and lymph node metastasis in colon cancer[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(02):157-159. DOI：

摘要

目的了解结肠癌肿瘤相关巨噬细胞中VEGF-C/D的表达，探讨其对结肠癌淋巴结转移的影响及可能机制。方法采用特异的巨噬细胞标记物CD68等抗体以免疫组化染色的方法，并用双染、连续切片对比等对45例结肠癌标本中巨噬细胞VEGF-C/D的表达进行检测，同时行巨噬细胞计数，并统计分析两者间存在的关系。结果在结肠癌相关巨噬细胞中检测到两种淋巴管生成因子的表达。统计分析显示VEGF-C表达与巨噬细胞计数具有相关性。有淋巴结转移者VEGF-C阳性细胞率高于无转移组。结论结肠癌肿瘤组织中，不仅肿瘤细胞可分泌表达VEGF-C/D，肿瘤相关巨噬细胞也可表达VEGF-C/D。肿瘤相关巨噬细胞可通过诱导结肠癌局部淋巴管生成，对肿瘤的转移可起到一定的作用。

Abstract

Objective To discuss the correlation between the VEGF-C/D expressions in tumor associated macrophage (TAM) and lymph node metastasis in colon cancer. Methods Forty-five colon cancer samples proven pathologically to be adenocarcinoma were stained by immunohistochemical method for VEGF-C/D and CD68. The correlation of VEGF-C/D expressions

macrophage counting and lymph node metastasis were analyzed statistically. Results The expressions of VEGF-C/D were detected in TAMs. VEGF-C expression was obviously higher in the samples with lymphatic metastasis. VEGF-C expression in colon cancer was related to the number of TAMs. Conclusion TAMs are important in the lymph node metastasis

because they can express VEGF-C/D and affect the lymphangiogenesis of colon cancer.

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