Correlation of gastric morphogenesis with proliferation and apoptosis of gastric epithelium in embryonic mice

林雪梅; 汪维伟; 李芳菲

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Correlation of gastric morphogenesis with proliferation and apoptosis of gastric epithelium in embryonic mice

更新时间：2026-01-09

- Correlation of gastric morphogenesis with proliferation and apoptosis of gastric epithelium in embryonic mice
- Journal of Army Medical University Vol. 29, Issue 1, Pages: 53-55(2007)
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  CLC： Q954.48;Q954.58
- Published：2007
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林雪梅,汪维伟,李芳菲.胎鼠胃上皮细胞增殖、凋亡与胃形态发生的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(01):53-55.

　LIN Xue-mei,WANG Wei-wei,LI Fang-fei.Correlation of gastric morphogenesis with proliferation and apoptosis of gastric epithelium in embryonic mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(01):53-55.
林雪梅,汪维伟,李芳菲.胎鼠胃上皮细胞增殖、凋亡与胃形态发生的关系[J].陆军军医大学学报(原第三军医大学学报),2007,29(01):53-55. DOI：

　LIN Xue-mei,WANG Wei-wei,LI Fang-fei.Correlation of gastric morphogenesis with proliferation and apoptosis of gastric epithelium in embryonic mice[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(01):53-55. DOI：

摘要

目的研究胎鼠胃上皮细胞增殖、凋亡的时空规律及其与胃形态发生的关系。方法每间隔0.5 d 取E11～15.5 d小鼠整胎

横断连续切片

观察胃形态发生，体视学法测量胃贲门、幽门、大弯、小弯上皮分裂细胞密度（DMC）、凋亡小体密度（DAB）。结果 ①E11.5 d胃开始发育

E12 d胃底膨出

胃大、小弯出现。②上皮细胞DMC峰值均在DAB峰值之前。③贲门处DMC无明显峰值，DAB峰值在E11.5、12.5、13.5 d；幽门处DMC峰值在E12.5 d，DAB峰值在E14 d；大弯DMC峰值在E11.5、12 d时

DAB值持续较低；小弯DMC峰值在E11.5 d，DAB峰值在E12.5 d。结论胎鼠胃上皮细胞的增殖及凋亡与胃发生有密切的时空关系。

Abstract

Objective To study the spatiotemporal distributions of epithelial proliferation and apoptosis

and the correlation of morphogenesis with them in developing stomach. Methods Serial sections of fetal mice aged 11-15.5 days were made. The morphogenesis of stomach was observed under light microscope. The density of mitotic cells (DMC) and apoptotic bodies (DAB) of epithelium in the developing cardia

pylorus

greater curvature

lesser curvature were measured with stereological method. Results The morphological development of stomach took place on the 11

day of mouse embryo development. The fundus

greater curvature and lesser curvature were observed on the 12

day. The p

eak value of DMC all appeared before the peak value of DAB. In the epithelium of cardia

no obvious peak value of DMC was observed and the peak value of DAB was on the 11.5

12.5

13.5

day. In the epithelium of pylorus

the peak value of DMC was on the 12.5

day

the peak value of DAB was on the 14

day. In the epithelium of greater curvature

the peak value of DMC was on the 11.5

and 12

day

the DAB value was low. In the epithelium of lesser curvature

the peak value of DMC was on the 11.5

day

the peak value of DAB was on the 12.5

day. Conclusion There was very close spatiotemporal relationship between the cell proliferation

cell apoptosis and the morphological development of stomach.

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