Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549

刘乐斌; 刘胜学; 胡孝贞; 杨录军; 敖琳; 周燕虹; 黄晓春; 曹佳

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Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549

更新时间：2026-01-09

- Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549
- Journal of Army Medical University Vol. 29, Issue 1, Pages: 18-20(2007)
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  CLC： R282.71;R73-361;R734.2
- Published：2007
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刘乐斌,刘胜学,胡孝贞,杨录军,敖琳,周燕虹,黄晓春,曹佳.昆明山海棠总生物碱诱导肺腺癌A549细胞凋亡与细胞周期改变[J].陆军军医大学学报(原第三军医大学学报),2007,29(01):18-20.

　LIU Le-bin,LIU Sheng-xue,HU Xiao-zhen,YANG Lu-jun,AO Lin,ZHOU Yan-hong,HUANG Xiao-chun,CAO Jia.Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(01):18-20.
刘乐斌,刘胜学,胡孝贞,杨录军,敖琳,周燕虹,黄晓春,曹佳.昆明山海棠总生物碱诱导肺腺癌A549细胞凋亡与细胞周期改变[J].陆军军医大学学报(原第三军医大学学报),2007,29(01):18-20. DOI：

　LIU Le-bin,LIU Sheng-xue,HU Xiao-zhen,YANG Lu-jun,AO Lin,ZHOU Yan-hong,HUANG Xiao-chun,CAO Jia.Effect of alkaloids from tripterygium hypoglaucum hutch on apoptosis of human lung adenocarcinoma cell line A549[J].J Amry Med Univ (J Third Mil Med Univ),2007,29(01):18-20. DOI：

摘要

目的为探讨昆明山海棠总生物碱(alkaloids from Tripterygium Hypoglaucum Hutch， THHa)抗肺癌机制，研究THHa诱导肺腺癌A549细胞凋亡与细胞周期改变的关系。方法应用形态学观察、DNA凝胶电泳、流式细胞仪检测分析肺腺癌A549细胞凋亡及细胞周期改变。结果 THHa能够诱导肺腺癌A549细胞凋亡并主要作用于细胞周期S期（S期细胞增多）。结论 THHa可能通过诱导细胞凋亡而抑制A549细胞增殖，这种作用与细胞周期有关，这些有助于将来肺癌治疗方案的合理设计。

Abstract

Objective To explore the mechanism of the alkaloids from tripterygium hypoglaucum hutch (THHa) on the apoptosis of lung cancer. Methods Apoptosis and cell cycle of human lung adenocarcinoma cell line A549 were detected by morphological observation

DNA electrophoresis

and flow cytometry.  Results THHa could induce apoptosis of human lung adenocarcinoma cell line and arrest the cells at S phase of cell cycle. Conclusion Apoptosis contributes to inhibitory effect of THHa on A549 cells. This may be helpful in designing an appropriate chemotherapeutic regimen in future.

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