1.西安医学院附属西北妇女儿童医院医学影像中心,西安 710068
2.西安邮电大学计算机学院,西安 710121
3.西北妇女儿童医院医学影像中心,西安 710061
Received:024 September 2025,
Published Online:18 November 2025,
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徐春琪,寇秀梅,李菊菊等.基于MRI影像组学的胎盘植入性疾病分型诊断[J].重庆医科大学学报,
Xu chunqi,Kou xiume,Li juju,et al.Diagnosis of placenta accreta spectrum disorder subtypes based on MRI radiomics[J].Journal of Chongqing Medical University,
徐春琪,寇秀梅,李菊菊等.基于MRI影像组学的胎盘植入性疾病分型诊断[J].重庆医科大学学报, DOI:10.13406/j.cnki.cyxb..
Xu chunqi,Kou xiume,Li juju,et al.Diagnosis of placenta accreta spectrum disorder subtypes based on MRI radiomics[J].Journal of Chongqing Medical University, DOI:10.13406/j.cnki.cyxb..
目的
2
基于核磁共振成像(magnetic resonance imaging,MRI)影像组学对胎盘植入性疾病的分型诊断的研究。
方法
2
回顾性分析127例胎盘植入性疾病患者(粘连性胎盘 52例、植入性胎盘54例、穿透性21例)的临床及MRI资料。通过3D Slicer手动勾画感兴趣区,使用Pyradiomics提取影像组学特征,LightGBM重要性排序和皮尔逊相关性分析筛选特征变量,应用逻辑回归方法构建临床模型、MRI特征模型、影像组学模型及医师诊断模型,采用留一法交叉验证,绘制受试者工作特征曲线(receiver operating characteristic,ROC)评价模型的效能。
结果
2
剖宫产次数、怀孕次数、宫颈管长度及胎盘厚度是胎盘植入性疾病(placenta accreta spectrum disorders,PAS)分型诊断的危险因素,其中胎盘厚度及宫颈管长度是植入性胎盘的独立危险因素;胎盘厚度是穿透性胎盘的独立危险因素。从 T2加权成像(T2-weighted imaging,T2WI)图像中提取并筛选出20个影像组学特征,用于构建影像组学模型。PAS分型诊断影像组学模型预测粘连性胎盘、植入性胎盘、穿透性胎盘的曲线下面积(area under the curve,AUC)分别为0.90、0.94及0.84,均优于临床指标模型、MRI影像特征模型及医师经验诊断模型。
结论
2
基于MRI影像组学模型预测PAS分型诊断效能较高,有助于产前明确PAS的不同植入程度。
Objective
2
To investigate magnetic resonance imaging(MRI ) radiomics-based subtype identification of placenta accreta spectrum disorder.
Methods
2
52 cases of placenta accreta,54 cases of placenta increta,and 21 cases of placenta percreta were among the 127 patients with placenta accreta spectrum disorder(PAS) whose clinical and MRI data were retrospectively analyzed. 3D Slicer was used to manually outline regions of interest. Pyradiomics was used to extractradiomic characteristics. LightGBM significance ranking and Pearson correlation analysis were used to screen feature variables. Clinical models,MRI feature models,radiomic models,and physician diagnosis models were all built using logistic regression. To assess the models' performance,receiver operating characteristic (ROC) curves were plotted and leave-one-out cross-validation was employed.
Results
2
The length of the cervical canal,the thickness of the placenta,the number of pregnancies,and the number of cesarean sections were risk factors for the diagnosis of the PAS subtype. For placenta increta,the placenta's thickness and the cervical canal's length were independent risk factors; for placenta percreta,the placenta's thickness was an independent risk factor. To build a radiomic model to predict PAS subtypes,19 radiomic characteristics were taken from T2WI pictures and screened. With AUC values of 0.90,0.84,and 0.94,respectively,the radiomic model outperformed the clinical model,MRI feature model,radiomic model,and physician diagnosis model when it came to diagnosing PAS subtypes.
Conclusion
2
In order to elucidate the various levels of placental invasion prior to delivery,the MRI-based radiomic model provides a comparatively excellent diagnostic performance for predicting PAS subtypes.
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